CHEMOTHERAPY OF AQUATICS

Chemical Therapy of Aquatics

Topic of Information – Identify the use of, a dose of, preparation of, and administration of drugs and chemicals in the treatment of ornamental fish.

Intention – To create a compilation of my experience and knowledge in a format that is easy to use and understand, that can be applied readily, to identify clear expectations with measurable results to help one understand what they are looking for during treatments.

Overview –  Below are chemicals and drugs listed in the treatment of ornamental livestock.
The topics listed below will be discussed and described in detail as they apply to that specific chemical or drug and its use, preparation, and administration, along with personal notes of my observations and applied practices and results, along with advice.


Preparation Methods - A

Administration Methods –

Topical

Baths

1. Dip
2. Short
3. Long
4. Constant Flow

Oral

Parenteral -Injections

1. Intramuscular
2. Intravenous
3. Intraperitoneal

My Notes

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ACRIFLAVINE

Additional Information

Acriflavine, neutral - This is a stock item that should be in every aquarist's medicine cabinet. Also is the yellow dye for tie-dye projects.

Composition – Mixture of 3,6-diamino-10-methylacridinum chloride and 3,6-diaminoacridine.

Uses or Treatment for – Dye; egg disinfection; antiseptic; infected wounds; ulcers, skin parasites (ectoparasites): bacteria(Columnaris); fungicide(Saprolegnia); external protozoacide (Ambiphyra, Chilodonella, Cryptocaryon irritans, Hexamita; Ichthyophthirius multifils (Ich), Oodinium ocellatum, O. pillularis, Scyphidia; Monogenea(Cleidodiscus).

Administration and Dosage -
1) 1gm/100 l of water
2) 2mg/gal of water
3) 1gm/100 l of water for 2 to 12 hours
4) 0.1% solution added to food
5) 3 to 10 ppm in water for a prolonged bath
7) 10 ppm for 10 hours
8) 0.2 to 0.6 ppm in two applications at 2-day intervals
9) 5 to 10 ppm added to water for several hours to several days
10) 500 ppm as a bath for 30 minutes

Observations, Notes, Remarks – Normally used as a long-duration bath; will kill live plants; may reduce fecundity in guppies; may damage slime coating of skin and create vulnerability to bacterial disease in marine fish; apply or soak foods for oral treatments, available as powder or solution. When I make my stock solution, I add 3.8gr Acriflavine and 1/4 cup of pickling salt per gallon for a kick.
Apply to freeze-dried foods, excellent for administering orally.
Seems to be more effective when dosed with Methyl Blue.

A close up of some brown dirt
Acriflavine Powder

MALACHITE GREEN

Additional Information

Malachite Green, zinc-free oxalate - This is a stock item that should be in every aquarist medicine cabinet. Also is the green dye for tie-dye projects.

Composition – p,p-benzylidenebis-N, N-dimethyl aniline

Synonyms – Aniline green, Bright Green, Evergreen B, Light green N, Malachite green sulfate, Malachite oxalate, Nox-Ich, Victoria green B or WB.

Uses or Treatments for – Ectoparasites; bacteria(Columnaris); fungicide(Achyla, Aphanomyces, Ichthyophonus hoferi, Saprolegnia); external protozoacide [Ambiphyra(Scyphidia), Chilodonella, Costia, Cryptocaryon irritans, Epistylis, Ichthyophthirius, Leptomitus, Oodinium ocellatum, O. pillularis, Pythium, Trichodina(Cyclochaeta), Trichophyra], monogenetic trematodes(Gyrodactylus).

Administration and Dosage -
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Observations, Notes, Remarks – When I make my stock solution, I use 3.68gr per quart of water; when I make an antiparasitic ICK OFF solution, I use formalin 37%.

A close up of some sort of substance
Malachite Green

ICK OFF - MALACHITE GREEN WITH FORMALIN 37%

Additional Information

ICK OFF is Malachite Green, zinc-free oxalate dissolved in Formalin 37% - This is a stock item that should be in every aquarist's medicine cabinet.

Composition – A

Synonyms – A

Uses or Treatments for – A

Administration and Dosage -
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Observations, Notes, Remarks – A

My Notes

When I make my stock solution, I use 3.68gr per quart of Formalin 37%. More is not better with this stuff. One drop per gallon; sensitive fish use one drop per two gallons.

METHYLENE BLUE

Additional Information

Methylene Blue - This is a stock item that should be in every aquarist medicine cabinet. Also is the blue dye for tie-dye projects.

Composition – 3,7-bis(dimethylamino)-phenazathionium chloride

Synonyms – Methylene blue-B; Methylthionine chloride; Urolene blue

Uses or Treatments for – Dye; antifungal agent on fish eggs; fungicide(Saprolegnia); external protozoacide [Ambiphyra(Scyphida), Chilodonella, Costia, Cryptocaryon irritans, Epistylis, Ichthyophthirius, Oodinium, Trichodina(Cyclochaeta), Trichophyra ]; Monogenetic trematodes(Cleidodiscus, Gyrodactylus).

Administration and Dosage -
1) 2 ppm daily
2) 3 cc of a 1% solution in 10l of water as long duration bath (3-5 days)
3) 10ppm not effective
4) 50ppm is inhibitory
5) 3ppm
6)0.15ppm CuSO4 - Citric Acid -0.2ppm Methylene Blue at 5-day intervals, 3 times, for marine
7) 5ppm
8) 1.0 tp 3.0ppm in water for 3 to 5 days
9) 0.2 to 0.4cc /l (of a stock solution of 1 gm to 100cc water)

Observations, Notes, Remarks – When I make my stock solution, I add 7.5gm(1Tblsp) to 1 gallon of water 

A black smiley face is shown in the dark.
Methylene Blue

NEOMYCIN

Additional Information

Neomycin - This is a stock item that should be in every aquarist's medicine cabinet. When in doubt, this one will take it out.

Composition – Neomycin Sulfate

Synonyms – Mycifradin sulfate, Neobiotic

Uses or Treatments for – Bacteria (gram-positive or gram-negative bacteria; Pseudomonas).

Administration and Dosage -
1) 250mg/gal in salt water

Observations, Notes, Remarks – Shelf live in solution is 2 years, very effective in salt water. Not pH sensitive, works well at high or low pH.

My Notes

One of the best as it treats both gram-positive and gram-negative bacteria. An absolute essential for saltwater Aquarian.

SODIUM CHLORIDE-SALT-NACL

Additional Information

Sodium Chloride, NaCl - This is a stock item that should be in every aquarist's medicine cabinet. It can enhance the action of, help with the uptake of, and enhance results when used in conjunction with other chemicals.

Composition – NaCl

Synonyms – Rock Salt, Table Salt (non-iodized), Pickling Salt

Uses or Treatments for – A

Administration and Dosage -
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Observations, Notes, Remarks – A

My Notes

Make sure to use non-iodized salt for additions to your aquarium or treatments. Pickling salt contains no iodine or flow agents.

POTASSIUM PERMANGANATE

Additional Information

Potassium Permanganate - This is a stock item that should be in every aquarium's medicine cabinet. For disinfecting equipment, nets dip new plants can run 3-5ppm in an aquarium, but better for your outdoor pond to keep large parasites in check. Also is the violet dye for tie-dye projects.

Composition – KMuO4

Uses or Treatments for – External parasites; external lesions; bacteria (bacteria on skin);
Fungi (Saprolegnia, achylasis); Protozoa (Costia, Chilodoneila, Cryptocaryon irritans, Epistylis, Ichthyophthirius, Ichthyobodo, Trichodina); Monogenea (Bededenia, Cleidodiscus, Dactylogyrus, Gyrodactylus); Hirudinea (leaches); Crustacea (Argulus, Lernaea).

Administration and Dosage -
1) 20ppm for one hour
2) 1gm/100l of water for a short bath of 90 minutes.
3) 1gm l of water immersion bath of 30–45 seconds
4) 1gm/10l of water, short bath of 5–10 seconds
5) 1gm /50l of water as a disinfectant
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Observations, Notes, Remarks – Not for the novice; Dosing is critical, more is not better, treatments are short, dips or short baths, very effective when used correctly.
  Awesome disinfectant for aquariums and equipment that you cannot boil (hoses, tubing, nets, PVC, thermometer, etc.) Fill the aquarium with water, put in all your stuff, add Potassium Permanganate until you can't see through it, let your filter run with no media so it gets all cleaned out, then let run for three days, then empty and rinse until no color left.

My Notes

Powerful disinfectant is quickly powerful against crustaceans and parasites.

MAGNESIUM SULFATE

Additional Information

Magnesium Sulfate - This is a stock item that should be in every aquarist medicine cabinet, also for making stock solutions for Reef Mag supplement.

Composition – A

Synonyms – A

Uses or Treatments for – A

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Observations, Notes, Remarks – A

My Notes

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